Keep an eye on Carefully (1)pentobarbital will increase the degree or impact of clopidogrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with potent CYP3A4 inducers; these drugs lowe